739898

Sigma-Aldrich

1α,25-Dihydroxyvitamin D2 solution

50 μg/mL in ethanol, 95% (CP)

别名:
1α,25-Dihydroxycalciferol solution
Empirical Formula (Hill Notation):
C28H44O3
CAS号:
分子量:
428.65
EC 号:
NACRES:
NA.24

质量水平

200

测定

95% (CP)

形式

solution

浓度

50 μg/mL in ethanol

应用

detection: suitable
mass spectrometry (MS): suitable

颜色

colorless

储存温度

−20°C

SMILES string

CC(O)(C)[C@@H](C)/C=C/[C@@H](C)[C@H]1CCC([C@]1(C)CCC/2)C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C

InChI

1S/C28H44O3/c1-18(9-10-19(2)27(4,5)31)24-13-14-25-21(8-7-15-28(24,25)6)11-12-22-16-23(29)17-26(30)20(22)3/h9-12,18-19,23-26,29-31H,3,7-8,13-17H2,1-2,4-6H3/b10-9+,21-11+,22-12-/t18-,19+,23-,24-,25?,26+,28-/m1/s1

InChI key

ZGLHBRQAEXKACO-KPKHAADHSA-N

正在寻找类似产品? Visit 产品对比指南

相关类别

一般描述

1α,25-Dihydroxyvitamin D2 is an active form of vitamin D2. It is also known as ercalcitriol or 1α,25-dihydroxyergocalciferol. It was first isolated from mitochondria of chick kidney.

应用

This product may be used as an analytical standard.

包装

1 mL in ampule

象形图

FlameExclamation mark

警示用语:

Danger

危险声明

预防措施声明

hazcat

Eye Irrit. 2 - Flam. Liq. 2

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 1

闪点(F)

57.2 °F - closed cup

闪点(C)

14 °C - closed cup

分析证书

原产地证书 (CofO)

Laura Sánchez-Abella et al.
Journal of medicinal chemistry, 52(19), 6158-6162 (2009-09-11)
We have synthesized several isomers of 19-nor-vitamin D analogues possessing a hydroxy group at C-2 as well as novel derivatives bearing an epoxy substituent at the A-ring. All vitamins were prepared in convergent syntheses utilizing the modified Julia olefination. 1alpha,2alpha,25-Trihydroxy-19-nor-vitamin...
Convergent synthesis of double point modified analogs of 1α, 25-dihydroxyvitamin D2 for biological evaluation
Nadkarni S, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 164, 45-49 (2016)
Yuka Inaba et al.
Journal of medicinal chemistry, 52(5), 1438-1449 (2009-02-06)
To identify novel vitamin D receptor (VDR) ligands that induce a novel architecture within the ligand-binding pocket (LBP), we have investigated eight 22-butyl-1alpha,24-dihydroxyvitamin D(3) derivatives (3-10), all having a butyl group as the branched alkyl side chain. We found that...
Masato Shimizu et al.
Bioorganic & medicinal chemistry, 16(14), 6949-6964 (2008-06-10)
Recently, we have found that 16-ene-22-thia-26,27-dimethyl-19-norvitamin D(3) analogs 1a (n=2, 3) are 20 times more active than the natural hormone 1alpha,25-dihydroxyvitamin D(3) in terms of transcriptional activity. To further investigate the effects of the A-ring modification of 1a, b on...
Marc Lamblin et al.
Bioorganic & medicinal chemistry, 18(11), 4119-4137 (2010-05-11)
Incorporation of zinc-binding groups into the side-chain of 1alpha,25-dihydroxyvitamin D(3) (1,25D) fully bifunctional hybrid molecules which act both as vitamin D receptor agonists and histone deacetylase inhibitors. These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma...
技术文章
This application shows an Ascentis Express F5 provided rapid resolution of the isobaric vitamin D metabolites. MS detection provides the necessary secondary resolution.
了解更多
相关内容
The metabolic role and health implications of the various vitamin D isoforms are of current clinical interest. Therefore, it is important to have an analytical method that will resolve all of the known isoforms with necessary sensitivity and specificity
了解更多

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门