Merck
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764019

Sigma-Aldrich

二苯基环辛炔-PEG4-氢化琥珀酰亚胺酯

≥90%

Synonym(s):
DBCO-PEG4-NHS酯, DBCO-PEG4-SE, DBCO-PEG4-氢化琥珀酰亚胺酯
Empirical Formula (Hill Notation):
C34H39N3O10
Molecular Weight:
649.69
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

质量水平

100

测定

≥90%

形式

paste

reaction suitability

reaction type: click chemistry

储存温度

−20°C

SMILES string

O=C(CCC(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI

1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38)

InChI key

RRCXYKNJTKJNTD-UHFFFAOYSA-N

应用

琥珀酰亚胺酯(NHS,胺反应活性)官能化环辛烷衍生物,用来将环辛烷部分插入含有化合物或生物分子的氨基找那个。环辛烷可以用于种促进免铜电极化学环加成反应。这一聚乙二醇会和叠氮官能化化合物或生物分子反应,而不需要Cu(I)催化,就能形成稳定的三唑连接。

应用包括:
  • 蛋白质-多肽偶联物
  • 抗体-酶或抗体药物偶联物
  • 蛋白质或多肽-寡核苷酸偶联物
  • 表面修饰
聚乙二醇-PEG4-N-氢化琥珀酰亚胺酯可以通过少铜点击反应,用来合成前列腺特异性膜抗体(PSMA)目标单光子发射计算体层摄影(SPECT)试剂。[1]

包装

1, 5, 50 mg in clear glass bottle

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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