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765392

Sigma-Aldrich

Gold nanoparticles

40 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O

别名:
Gold nanoparticles NH2 functionalized, Gold Colloid, Au NP NH2

质量水平

100

物料

PEG 5000

形式

dispersion in H2O
nanoparticles

包装

poly bottle of 1 mL

OD

50

直径

40 nm

pH值(酸碱度)

6.0-8.0 (25 °C)

溶解性

water: miscible

密度

1.00 g/cm3

官能团

amine

储存温度

2-8°C

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一般描述

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. AuNPs, as aggregates, is shown to be highly sensitive colloidal biosensors. Poly (ethylene) glycol (PEG) surface coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which has Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.

应用

Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs are used in cellular and intracellular targeting in targeted drug delivery applications and can also be used in biodistribution studies
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.
  • They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.

包装

1 mL in poly bottle

特点和优势

  • A negatively charged siRNA-PEG complex attached to positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
  • The PEG coating decreases the cytotoxicity and increases effciciency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Sarah D Brown et al.
Journal of the American Chemical Society, 132(13), 4678-4684 (2010-03-17)
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of...
Scott H Brewer et al.
Langmuir : the ACS journal of surfaces and colloids, 21(20), 9303-9307 (2005-09-21)
The interaction of bovine serum albumin (BSA) with gold colloids and surfaces was studied using zeta-potential and quartz crystal microbalance (QCM) measurements, respectively, to determine the surface charge and coverage. The combination of these two measurements suggests that BSA binding...
Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of...
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells...
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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