765449

Sigma-Aldrich

Gold nanoparticles

5 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O

别名:
Gold nanoparticles COOH functionalized, Gold Colloid, Au NP COOH
PubChem化学物质编号:
NACRES:
NA.23

质量水平

100

物料

PEG 5000

形式

dispersion in H2O
nanoparticles

包装

glass bottle of 1 mL

OD

50

直径

5 nm

pH值(酸碱度)

6.0-8.0 (25 °C)

溶解性

water: miscible

密度

1.00 g/cm3

λmax

515 nm

官能团

carboxyl

储存温度

2-8°C

应用

Carboxylic acid functionalized, PEG 5000 coated and H2O dispersed gold nanoparticles (5 nm) can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It may also be used in immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

包装

1 mL in glass bottle

特点和优势

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration.

其他说明

  • form dispersion in H2O
  • OD 50
  • diameter 5 nm
  • storage temp. 2-8°C

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Jennifer Mytych et al.
BioMed research international, 2015, 304575-304575 (2015-07-23)
Nanogold-based materials are promising candidate tools for nanobased medicine. Nevertheless, no conclusive information on their cytotoxicity is available. In the present study, we investigated the effects of gold nanoparticles (AuNPs) on human astrocytes in vitro. Nanogold treatment in a wide...
Alexandre Albanese et al.
ACS nano, 5(7), 5478-5489 (2011-06-23)
Aggregation appears to be a ubiquitous phenomenon among all nanoparticles and its influence in mediating cellular uptake and interactions remain unclear. Here we developed a simple technique to produce transferrin-coated gold nanoparticle aggregates of different sizes and characterized their uptake...
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 6, 2071-2071 (2020)
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Sarah D Brown et al.
Journal of the American Chemical Society, 132(13), 4678-4684 (2010-03-17)
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of...
技术文章
The recent emergence of a number of highly functional nanomaterials has enabled new approaches to the understanding, diagnosis, and treatment of cancer.
了解更多
Biomaterials science involves the design and fabrication of smart materials for studying, directing, or mimicking biology. For successful integration of biomaterials in biological research, a meaningful understanding of biological systems is required.
了解更多
相关内容
最近出现的许多高功能纳米材料为癌症的认识、诊断和治疗提供了新的方案。
了解更多

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门