Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.
The carboxylic acid group binds with various proteins and is used in targeted drug delivery and gene therapy.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain...
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.