765562

Sigma-Aldrich

Gold nanoparticles

40 nm diameter, carboxylic acid functionalized, PEG 5000 coated, OD 50, dispersion in H2O

别名:
Gold nanoparticles COOH functionalized, Gold Colloid, Au NP COOH

质量水平

100

物料

PEG 5000

形式

dispersion in H2O
nanoparticles

包装

poly bottle of 1 mL

OD

50

直径

40 nm

pH值(酸碱度)

6.0-8.0 (25 °C)

溶解性

water: miscible

密度

1.00 g/cm3

λmax

530 nm

官能团

carboxyl

储存温度

2-8°C

正在寻找类似产品? Visit 产品对比指南

一般描述

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between the negatively charged carboxylate groups and positively charged amino groups of protein. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.

应用

Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies.
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
  • Carboxylic acid end-group binds with various proteins and can be used in targeted drug delivery and gene therapy.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

包装

1 mL in poly bottle

特点和优势

The PEG coating decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain...
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells...
Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of...
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)
技术文章
The recent emergence of a number of highly functional nanomaterials has enabled new approaches to the understanding, diagnosis, and treatment of cancer.
了解更多
Biomaterials science involves the design and fabrication of smart materials for studying, directing, or mimicking biology. For successful integration of biomaterials in biological research, a meaningful understanding of biological systems is required.
了解更多
相关内容
最近出现的许多高功能纳米材料为癌症的认识、诊断和治疗提供了新的方案。
了解更多

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门