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765732

Sigma-Aldrich

Gold nanoparticles

30 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O

别名:
Au NP OMe, Gold nanoparticles OMe terminated, Gold Colloid
NACRES:
NA.23

质量水平

100

物料

PEG 5000

形式

dispersion in H2O
nanoparticles

包装

glass bottle of 1 mL

OD

50

直径

30 nm

pH值(酸碱度)

6.0-8.0 (25 °C)

溶解性

water: miscible

密度

1.00 g/cm3

λmax

525 nm

官能团

methoxy

储存温度

2-8°C

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一般描述

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields.They show excellent biocompatibility and attractive physicochemical properties. AuNPs, as aggregates, are shown to be highly sensitive colloidal biosensors. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles. PEG layer density depends inversely on the AuNPs curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. The methyl group, being hydrophobic, acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.

应用

Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs can be used in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.
  • AuNPs can be used in photothermal therapy and radiotherapy.
  • Studies show that 30-nm PEG-coated AuNPs have been successfully used to deliver tumor necrosis factor to solid tumors.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

包装

1 mL in glass bottle

特点和优势

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.

Storage Class Code

10 - Combustible liquids

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Guodong Zhang et al.
Biomaterials, 30(10), 1928-1936 (2009-01-10)
Polyethylene glycol (PEG)-coated (pegylated) gold nanoparticles (AuNPs) have been proposed as drug carriers and diagnostic contrast agents. However, the impact of particle characteristics on the biodistribution and pharmacokinetics of pegylated AuNPs is not clear. We investigated the effects of PEG...
Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of...
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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