808938

Sigma-Aldrich

金纳米颗粒

70 nm diameter, biotin terminated, PEG 5000, OD 50, dispersion in H2O

别名:
Biotin Gold
NACRES:
NA.23

质量水平

100

物料

PEG 5000

形式

dispersion in H2O
nanoparticles

组成

, 6.00E+11 particles/mL

包装

pkg of 0.5 mL

储存条件

do not freeze

浓度

2.09 mg/mL in H2O

OD

50

直径

70 nm

表面积

4.43 m2/g

pH值(酸碱度)

5-7

密度

1.00 g/cm3

peak SPR wavelength

548 nm

官能团

biotin

储存温度

2-8°C

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一般描述

Gold nanoparticles PEG 5000 biotin terminated. The preparation of biotinylated gold nanoparticles involves two surface modification steps. First, the carboxyl-terminated alkanethiol is attached to the surface of gold nanoparticles via chemisorption in the presence of a stabilizing agent. This step is followed by the reaction of the carboxyl groups with (+)-biotinyl-3,6,9,-trioxaundecanediamine and 2-(2-aminoethoxy)ethanol.

应用

Biotin functionalized gold nanoparticles are suitable for binding of streptavidin labelled conjugates. The gold nanoparticle label allows for straightforward detection of streptavidin by measuring the increase in absorbance of the sample upon binding. The absorption maximum is gold nanoparticle size dependent and ranges from 515-520nm for a 5nm particle to 572nm for a 100nm particle.
Gold nanoparticles 70 nm diameter, biotin terminated, PEG 5000, OD 50, dispersion in H2O can be used as a theranostic agent for potential usage in cancer therapy and treatment of COVID-19. It can also be used in the detection of pathogens for biosensing applications. AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.

法律信息

Product of CytoDiagnostics, Inc.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 1

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

Controlled and reversible aggregation of biotinylated gold nanoparticles with streptavidin.
Aslan K
The Journal of Physical Chemistry B, 108 (40), 15631-15639 (2004)
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 33(6), 666-680 (2020)
Colorimetric biosensing of pathogenss using gold nanoparticles
Verma MS, et al.
Biotechnology Advances, 33(6), 666-680 (2015)
Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy
Heo DN, et al.
Biomaterials, 33(3), 856-866 (2012)
Localized surface plasmon resonance (LSPR) of polyelectrolyte-functionalized gold-nanoparticles for bio-sensing
Li X, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 332(2-3), 172-179 (2009)

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