901362

Sigma-Aldrich

N-Sulfinyltritylamine

别名:
(Tritylimino)-sulfanone, TrNSO
Empirical Formula (Hill Notation):
C19H15NOS
CAS号:
分子量:
305.39

Quality Level

assay

≥95%

form

powder or crystals

mp

98 °C

storage temp.

−20°C

Application

N-Sulfinyltritylamine, TrNSO, is a stable linchpin reagent for the one-pot synthesis of diverse sulfonimidamides. Reported by the laboratory of Michael Willis, TrNSO can be used to join organometallic reagents and amines to assemble differentially substituted sulfonimidamides in high yields. TrNSO will find utility in medicinal and agrochemistry applications where more efficient synthetic methods are required for this increasingly significant functional group.

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Thomas Q Davies et al.
Angewandte Chemie (International ed. in English), 56(47), 14937-14941 (2017-09-21)
Sulfonimidamides are increasingly important molecules in medicinal chemistry and agrochemistry, but their preparation requires lengthy synthetic sequences, which has likely limited their use. We describe a one-pot de novo synthesis of sulfonimidamides from widely available organometallic reagents and amines. This convenient...

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