902527

Sigma-Aldrich

Amino-PEG5-t-butyl ester

≥95%

别名:
tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate, H2N-PEG5-CH2CH2COOtBu
Empirical Formula (Hill Notation):
C17H35NO7
CAS号:
分子量:
365.46
MDL number:

assay

≥95%

form

liquid

reaction suitability

reagent type: cross-linking reagent

refractive index

n/D 1.4534

density

1.4690 g/mL

storage temp.

−20°C

SMILES string

NCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

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