Merck

902551

Sigma-Aldrich

BocNH-PEG4-acid

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别名:
2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid, Boc-NH-PEG4-CH2COOH
Empirical Formula (Hill Notation):
C15H29NO8
分子量:
351.39

形式

liquid

reaction suitability

reaction type: Pegylations
reagent type: cross-linking reagent

折射率

n/D 1.4641

密度

1.1395 g/mL

官能团

Boc
amine
carboxylic acid

储存温度

−20°C

SMILES string

OC(COCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

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902683902675QBD10760
BocNH-PEG4-acid

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902551

BocNH-PEG4-acid

BocNH-PEG5-acid

Sigma-Aldrich

902683

BocNH-PEG5-acid

BocNH-PEG6-acid

Sigma-Aldrich

902675

BocNH-PEG6-acid

reaction suitability

reaction type: Pegylations, reagent type: cross-linking reagent

reaction suitability

reaction type: Pegylations, reagent type: cross-linking reagent

reaction suitability

-

reaction suitability

reaction type: Pegylations

refractive index

n/D 1.4641

refractive index

-

refractive index

n/D 1.4657

refractive index

-

density

1.1395 g/mL

density

-

density

-

density

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

functional group

Boc

functional group

Boc, amine, carboxylic acid

functional group

Boc, amine, carboxylic acid

functional group

-

应用

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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A biocompatible condensation reaction for the labeling of terminal cysteine residues on proteins.
Hongjun Ren et al.
Angewandte Chemie (International ed. in English), 48(51), 9658-9662 (2009-11-20)
BisPNA targeting to DNA: Effect of neutral loop on DNA duplex strand invasion by aepPNA-N7GlaepPNA-C substituted peptide nucleic acids
Shirude P S, et sl.
European Journal of Organic Chemistry, 2005, 5207-5215 (2005)
Jennifer L Brigham et al.
ACS chemical biology, 8(4), 691-699 (2013-01-12)
Bioorthogonal ligation methods that allow the selective conjugation of fluorophores or biotin to proteins and small molecule probes that contain inert chemical handles are an important component of many chemical proteomic strategies. Here, we present a new catch-and-release enrichment strategy
Zinc(II) cyclen-peptide conjugates interacting with the weak effector binding state of RaS.
Rosnizeck I C, et al.
Inorgorganica Chimica Acta, 365 (1), 38-48 (2011)
Erin A Losey et al.
Bioconjugate chemistry, 20(2), 376-383 (2009-01-16)
Cellular membranes play key roles in the regulation of a range of important biological processes. However, the characterization of membrane involvement in these events is difficult to achieve due to the complexity of the membrane bilayer and the challenges associated

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