Merck
All Photos(2)

904872

Sigma-Aldrich

Pomalidomide-PEG2-butyl azide

≥95%

All Photos(2)
Synonym(s):
2-(2-((6-Azidohexyl)oxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide, Crosslinker−E3 Ligase ligand conjugate, Pomalidomide-2-2-6-N3, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
Empirical Formula (Hill Notation):
C23H28N6O7
Molecular Weight:
500.50

检测方案

≥95%

形式

powder or crystals

reaction suitability

reaction type: click chemistry
reagent type: ligand-linker conjugate

官能团

azide

储存温度

2-8°C

SMILES string

O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCCCCCN=[N+]=[N-])=O)=O)NC1=O

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Pomalidomide-PEG2-butyl azide ≥95%

Sigma-Aldrich

904872

Pomalidomide-PEG2-butyl azide

Pomalidomide-PEG6-butyl azide ≥95%

Sigma-Aldrich

903434

Pomalidomide-PEG6-butyl azide

Pomalidomide-C6-PEG1-C3-PEG1-butyl azide ≥95%

Sigma-Aldrich

904880

Pomalidomide-C6-PEG1-C3-PEG1-butyl azide

Pomalidomide-PEG4-Azide ≥95%

Sigma-Aldrich

909386

Pomalidomide-PEG4-Azide

assay

≥95%

assay

≥95%

assay

≥95%

assay

≥95%

form

powder or crystals

form

powder or crystals

form

powder or crystals

form

powder or solid

reaction suitability

reaction type: click chemistry

reaction suitability

reaction type: click chemistry, reagent type: ligand-linker conjugate

reaction suitability

reaction type: click chemistry, reagent type: ligand-linker conjugate

reaction suitability

reaction type: click chemistry, reagent type: ligand-linker conjugate

functional group

azide

functional group

azide

functional group

azide

functional group

azide

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

应用

Protein degrader builiding block Pomalidomide-PEG2-Butyl Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

其他说明

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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