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KITALYSIS-RCM

Sigma-Aldrich

KitAlysis High-Throughput Medium (5, 6, 7) Ring Closing Metathesis Reaction Screening Kit - Pack of 2

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

储存温度

2-8°C

应用

Screening kit for ring closing metathesis. Step-by-step user guides and a downloadable experimental excel sheets are provided in the below hyperlinks.
Step-by-Step Guide for Ring Closing Metathesis/Cross Metathesis Reaction Screening Kit Downloadable Experiment excel sheets

Each kit contains 2 customizable screening sets that include the following components:
  • 6x4 pre-weighed catalysts in glass microvials loaded with stir bars and topped with cap mat.
  • 2 (2 mL) ampules each of of ClPh, PhMe, i-PrOAc, Me-THF, and TFA.
  • 1 KitAlysis 24-well reaction block replacement film.
  • 4 empty substrate stock solution reaction vials with stir bars.
  • 1 internal standard.

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

特点和优势

  • Designed and tested by synthetic chemists.
  • Easily run 24-microscale reaction in parallel.
  • 20 μmol reactions with 1 μmol catalyst (5 mol%), 0.2 M concentration, and optional TFA additive.
  • Customizable and downloadable excel template for quick calculations and easy incorporation into electronic laboratory notebooks.

法律信息

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

试剂盒组分也可单独购买

产品编号
说明
化学品安全说明书

  • 569747Grubbs Catalyst® M204, Umicore 3 µmol

  • 569755Hoveyda-Grubbs Catalyst® M720, Umicore, 97% 3 µmol

  • 579726Grubbs Catalyst® M102, Umicore, 97% 3 µmol

  • 682365Grubbs Catalyst® M207, Umicore 3 µmol

  • 682373Hoveyda-Grubbs Catalyst® M721, Umicore 3 µmol

  • 729345Hoveyda-Grubbs Catalyst® M722, Umicore 3 µmol

  • 900519Isopropyl acetate, anhydrous, ZerO2®, ≥99.6% 8 mL

  • 9005202-Methyltetrahydrofuran, anhydrous, contains 250 ppm BHT as stabilizer, ZerO2®, ≥99.0% 8 mL

  • 900521Chlorobenzene, anhydrous, ZerO2®, 99.8% 8 mL

  • 900522Toluene, anhydrous, ZerO2®, 99.8% 8 mL

  • Z118850Spinbar® magnetic stirring fleas, red, L 10 mm, diam. 3 mm 1 EA

  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

查看所有结果 (12)

警示用语:

Danger

危险分类

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Sol. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

靶器官

Central nervous system

补充剂危害

储存分类代码

4.1B - Flammable solid hazardous materials

WGK

WGK 3

分析证书

原产地证书 (CofO)

Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Karl D Collins et al.
Nature chemistry, 6(10), 859-871 (2014-09-23)
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical
High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in

技术文章

KitAlysis™ High-Throughput Screening Platform

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

实验方案

Catalyst Screening followed by TLC-MS for Reaction Progress Analysis using KitAlysis™

Catalyst screening, KitAlysis™ High-Throughput Screening Kits, Thin layer chromatography (TLC), parallel analysis, parallel synthesisigh-Throughput Buchwald-Hartwig Amination Reaction Screening Kit, TLC-MS analysis

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