Merck

QBD10011

Sigma-Aldrich

Phthalimidooxy-dPEG®4-NHS ester

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经验公式(希尔记法):
C23H28N2O11
分子量:
508.48
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

检测方案

>90%

形式

solid or viscous liquid

reaction suitability

reactivity: amine reactive
reagent type: cross-linking reagent
reactivity: thiol reactive

官能团

NHS ester

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

SMILES string

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O

比较类似商品

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显示差异

1 of 4

此商品
QBD10109QBD10127QBD10081
vibrant-m

QBD10011

Phthalimidooxy-dPEG®4-NHS ester

vibrant-m

QBD10109

Acid-dPEG®5-NHS ester

vibrant-m

QBD10127

Acid-dPEG®13-NHS ester

vibrant-m

QBD10081

4-formyl-benzamido-dPEG®12-TFP ester

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

functional group

NHS ester

functional group

NHS ester, carboxylic acid

functional group

-

functional group

-

reaction suitability

reactivity: amine reactive, reagent type: cross-linking reagent
reactivity: thiol reactive

reaction suitability

-

reaction suitability

-

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

特点和优势

Phthalimidooxy-dPEG®4-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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