QBD10140

Acid-dPEG^®₂₅-NHS ester

>95% (HPLC)

• 别名: Acid-PEG-NHS ester, Acid-PEG₂₅-NHS ester, Carboxy-PEG₂₅-NHS ester, NHS-PEG₁₅₀₀-COOH, NHS-PEG₂₅-COOH
• Empirical Formula (Hill Notation): C₅₈H₁₀₉NO₃₁
• 分子量: 1316.47
• MDL编号: MFCD28976694

属性

• 检测方案: >95% (HPLC)
• 形式: solid or viscous liquid
• reaction suitability: reaction type: Pegylations
• 聚合物结构设计: shape: linear; functionality: heterobifunctional
• 运输: ambient
• 储存温度: −20°C

说明

特点和优势

Acid-dPEG₂₅-NHS ester is an amine-reactive crosslinker designed to facilitate intermolecular crosslinking with free amines at each end of the crosslinker through a single molecular weight, discrete polyethylene glycol (dPEG) backbone. The correct use of this product eliminates intramolecular crosslinking. The dPEG backbone is amphiphilic. Consequently, it imparts water solubility to molecules to which it is conjugated. The dPEG spacer is 79 atoms (92.5 Å) long. The dPEG spacer in this product is the monodisperse PEG equivalent of PEG₁₀₀₀. One end of the chain terminates in a propionic acid group. The other end terminates as the N-hydroxysuccinimidyl (NHS) ester of propionic acid. While both ends of the molecule can react with free amines such as the ε-amine group of lysine, only one end of the dPEG spacer is activated as the NHS ester. This construction permits only one end of the spacer to react at a time, thus giving the user greater control over crosslinking molecules using this product.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(F): Not applicable
• 闪点(C): Not applicable