Merck
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文件

QBD10247

Sigma-Aldrich

Thiol-dPEG®4-acid

>95% (HPLC)

所有图片(1)
别名:
Carboxy-PEG4-thiol, HS-PEG4-COOH, Thiol-PEG-acid, Thiol-PEG4-COOH, Thiol-PEG4-acid
Empirical Formula (Hill Notation):
C11H22O6S
分子量:
282.35
MDL编号:
MFCD11041132

检测方案

>95% (HPLC)

形式

solid or viscous liquid

reaction suitability

reaction type: Pegylations

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

特点和优势

Thiol-dPEG4-acid is a sulfhydryl-containing, crosslinking PEGylation reagent that has a cross-bridge of monodisperse polyethylene glycol. The single molecular weight, discrete-length PEG (dPEG) chain is 16 atoms (18.3 Å) long. The sulfhydryl end of the crosslinker reacts with gold (forming dative bonds) and with thiol-reactive functional groups such as maleimide, bromoacetyl, SPDP, and thiol. The carboxylic acid end of the molecule couples to free amines using EDC or any suitable carbodiimide. An acylating agent such as N-hydroxysuccinimide (NHS) or 2,3,5,6-tetrafluorophenol (TFP) can enhance coupling efficiency. The carboxylate must react after the sulfhydryl conjugation.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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