Merck
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文件

QBD10273

Sigma-Aldrich

Fmoc-N-amido-dPEG®8-acid

>95% (HPLC)

所有图片(1)
别名:
Fmoc-N-amido-PEG8-COOH, Fmoc-N-amido-PEG8-acid, Fmoc-NH-PEG8-acid, Fmoc-PEG-acid
Empirical Formula (Hill Notation):
C34H49NO12
分子量:
663.75
MDL编号:
MFCD11041143

检测方案

>95% (HPLC)

形式

solid or viscous liquid

reaction suitability

reaction type: Pegylations

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

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此商品
QBD10243QBD10903QBD10613
Fmoc-N-amido-dPEG®8-acid >95% (HPLC)

Sigma-Aldrich

QBD10273

Fmoc-N-amido-dPEG®8-acid

Fmoc-N-amido-dPEG®2-acid >95% (HPLC)

Sigma-Aldrich

QBD10243

Fmoc-N-amido-dPEG®2-acid

Fmoc-N-amido-dPEG®36-acid >95% (HPLC)

Sigma-Aldrich

QBD10903

Fmoc-N-amido-dPEG®36-acid

Fmoc-N-Lys-(dPEG®4-biotin)-OH-(acid) >95% (HPLC)

Sigma-Aldrich

QBD10613

Fmoc-N-Lys-(dPEG®4-biotin)-OH-(acid)

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Biotinylations, reaction type: Pegylations

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: homobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

特点和优势

Fmoc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atom dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEGn-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificates of Analysis (COA)

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Guangchang Zhou et al.
Molecular bioSystems, 8(9), 2395-2404 (2012-07-10)
Robust methods for highly parallel, quantitative analysis of cellular protein tyrosine kinase activities may provide tools critically needed to decipher oncogenic signaling, discover new targeted drugs, diagnose cancer and monitor patients. Here, we describe proof-of-principle for a novel protein kinase
Ignacio Melgar-Asensio et al.
Investigative ophthalmology & visual science, 59(10), 4071-4081 (2018-08-12)
Drug delivery by intravitreal injection remains problematic, small agents and macromolecules both clearing rapidly. Typical carriers use microparticles (>2 μm), with size-related liabilities, to slow diffusion. We recently described cationic nanoparticles (NP) where conjugated Arg peptides prolonged residence in rat
Ian W Hamley
Biomacromolecules, 15(5), 1543-1559 (2014-04-12)
The remarkable diversity of the self-assembly behavior of PEG-peptides is reviewed, including self-assemblies formed by PEG-peptides with β-sheet and α-helical (coiled-coil) peptide sequences. The modes of self-assembly in solution and in the solid state are discussed. Additionally, applications in bionanotechnology
Jared F Stefanick et al.
ACS nano, 7(9), 8115-8127 (2013-09-06)
Ligand-targeted nanoparticles are emerging drug delivery vehicles for cancer therapy. Here, we demonstrate that the cellular uptake of peptide-targeted liposomes and micelles can be significantly enhanced by increasing the hydrophilicity of the targeting peptide sequence while simultaneously optimizing the EG

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