Merck
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文件

QBD10275

Sigma-Aldrich

MAL-dPEG®8-acid

>95% (HPLC)

所有图片(1)
别名:
Carboxy-PEG-maleimide, Carboxy-PEG8-maleimide, MAL-PEG400-acid, MAL-PEG8-COOH, MAL-PEG8-acid
Empirical Formula (Hill Notation):
C26H44N2O13
分子量:
592.63
MDL编号:
MFCD13184956

检测方案

>95% (HPLC)

形式

solid or viscous liquid

reaction suitability

reaction type: Pegylations

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

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此商品
QBD10909QBD10773QBD10140
MAL-dPEG®8-acid >95% (HPLC)

Sigma-Aldrich

QBD10275

MAL-dPEG®8-acid

m-dPEG®37-acid >95% (HPLC)

Sigma-Aldrich

QBD10909

m-dPEG®37-acid

dPEG®24-biotin acid >95% (HPLC)

Sigma-Aldrich

QBD10773

dPEG®24-biotin acid

Acid-dPEG®25-NHS ester >95% (HPLC)

Sigma-Aldrich

QBD10140

Acid-dPEG®25-NHS ester

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Biotinylations, reaction type: Pegylations

reaction suitability

reaction type: Pegylations

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

特点和优势

MAL-dPEG8-acid is a monodisperse crosslinker that joins sulfhydryl groups to free amines through a single molecular weight polyethylene glycol (PEG) chain of discrete length. The linker is 34 atoms and 38.8 Å long. The maleimidopropyl moiety reacts with sulfhydryl groups via a Michael addition reaction. The propionic acid terminus of the molecule reacts directly with free amines using EDC or another carbodiimide to form amide bonds. Alternatively, activation of the propionic acid group with N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), or some other acylating agent permits amide bond formation under mild, controlled conditions.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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Sara Movassaghian et al.
Molecular pharmaceutics, 13(8), 2605-2621 (2016-05-26)
Basal-like breast cancer (BLBC) accounts for the most aggressive types of breast cancer, marked by high rates of relapse and poor prognoses and with no effective clinical therapy yet. Therefore, investigation of new targets and treatment strategies is more than

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