Merck

QBD10376

Sigma-Aldrich

SPDP-dPEG®8-NHS ester

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经验公式(希尔记法):
C31H49N3O13S2
分子量:
735.86
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

检测方案

>90%

形式

solid or viscous liquid

反应适用性

reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive

官能团

NHS ester

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

SMILES字符串

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCSSC2=NC=CC=C2

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
QBD10378QBD10011QBD10379
vibrant-m

QBD10376

SPDP-dPEG®8-NHS ester

vibrant-m

QBD10378

SPDP-dPEG®12-NHS ester

vibrant-m

QBD10011

Phthalimidooxy-dPEG®4-NHS ester

vibrant-m

QBD10379

SPDP-dPEG®24-NHS ester

assay

>90%

assay

>90%

assay

>90%

assay

>90%

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

特点和优势

SPDP-dPEG®8-NHS ester has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. Protein aggregation and precipitation also are greatly reduced with SPDP-dPEG crosslinkers compared to crosslinkers that have only hydrocarbon spacers. dPEG spacer of specific length (37.2 Å) provides precise distance control between the SPDP moiety and the target molecule. Pyridyldithiol reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT). Crosslinking experiments with SPDP reagents are not limited to those involving proteins. Any of a variety of molecules with primary amines and sulfhydryl groups can be modified or crosslinked using SPDP reagents.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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