Merck

QBD10379

Sigma-Aldrich

SPDP-dPEG®24-NHS ester

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Empirical Formula (Hill Notation):
C63H113N3O29S2
分子量:
1440.70
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

检测方案

>90%

形式

solid or viscous liquid

reaction suitability

reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

SMILES string

O=C(CCSSC1=NC=CC=C1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

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此商品
QBD10119QBD10109QBD11203
SPDP-dPEG®24-NHS ester

Sigma-Aldrich

QBD10379

SPDP-dPEG®24-NHS ester

Acid-dPEG®9-NHS ester

Sigma-Aldrich

QBD10119

Acid-dPEG®9-NHS ester

Acid-dPEG®5-NHS ester

Sigma-Aldrich

QBD10109

Acid-dPEG®5-NHS ester

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

-

reaction suitability

-

reaction suitability

reactivity: thiol reactive, reagent type: cross-linking reagent
reactivity: amine reactive

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

特点和优势

SPDP-dPEG®24-NHS ester has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. Protein aggregation and precipitation also are greatly reduced with SPDP-dPEG crosslinkers compared to crosslinkers that have only hydrocarbon spacers. dPEG spacer of specific length (97.3 Å) provides precise distance control between the SPDP moiety and the target molecule. Pyridyldithiol reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT). Crosslinking experiments with SPDP reagents are not limited to those involving proteins. Any of a variety of molecules with primary amines and sulfhydryl groups can be modified or crosslinked using SPDP reagents.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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