Merck
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QBD10503

Sigma-Aldrich

叠氮基-dPEG®8-NHS酯

Empirical Formula (Hill Notation):
C23H40N4O12
CAS Number:
Molecular Weight:
564.58
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

测定

>90%

形式

solid or viscous liquid

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

SMILES string

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

特点和优势

叠氮基-dPEG®8-NHS酯在单个分子量dPEG®间隔基(32.2Å)的一端包含叠氮化物官能团,在间隔基的另一端包含反应性基团(NHS酯)。dPEG®间隔基具有亲水性和非免疫原性,提高了靶标分子的水溶性,同时降低免疫原性和增加靶标的流体动力学体积。N-羟基琥珀酰亚胺(NHS)酯在水溶液或有机溶剂中容易与胺类反应。叠氮化物基团在众所周知的点击化学反应中与炔烃反应。点击化学反应通过铜(I)或钌催化或与某些类型的炔烃伙伴的应变催化反应进行。

法律信息

受美国专利#7,888,536 B2保护的产品
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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