Merck
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QBD10774

Sigma-Aldrich

NHS-dPEG®24-biotin

Empirical Formula (Hill Notation):
C65H120N4O30S
Molecular Weight:
1469.72
PubChem化学物质编号:
NACRES:
NA.22

测定

>90%

形式

solid or viscous liquid

reaction suitability

reaction type: Biotinylations
reactivity: amine reactive

reagent type: cross-linking reagent

聚合物结构设计

shape: linear
functionality: monofunctional

运输

ambient

储存温度

−20°C

SMILES string

O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O

一般描述

NHS-dPEG®24-biotin is a cross-linking reagent used in biotinylation reactions. The N-hydroxysuccinimidyl (NHS) moiety of NHS-dPEG®24-biotin forms a stable amide bond with free primary amines, such as the amines on the side chain of lysine. The biotin moiety is used in a variety of applications, including labeling, supramolecular building, affinity chromatography, pull-down assays, and the production of biotinylated antibodies.[1]

特点和优势

NHS-dPEG®24-biotin is used extensively to label molecules that contain a free amine with biotin. The single molecular weight NHS-dPEG®24-biotin compound has a long spacer of precise length (97.7 Å) between the biotin moiety and the labeled molecule. This dPEG® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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