Merck
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文件

QBD10850

Sigma-Aldrich

Thiol-dPEG®12-acid

>95% (HPLC)

所有图片(1)
别名:
CT(PEG)12, Carboxy-PEG-Thiol, Carboxy-PEG12-Thiol, HS-PEG12-COOH, Thiol-PEG12-acid
Empirical Formula (Hill Notation):
C27H54O14S
分子量:
634.77
MDL编号:
MFCD21363238

检测方案

>95% (HPLC)

形式

solid or viscous liquid

reaction suitability

reaction type: Pegylations

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

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此商品
QBD10247JKA13002JKA4105
Thiol-dPEG®12-acid >95% (HPLC)

Sigma-Aldrich

QBD10850

Thiol-dPEG®12-acid

Thiol-dPEG®4-acid >95% (HPLC)

Sigma-Aldrich

QBD10247

Thiol-dPEG®4-acid

mPEG12-Propionic acid

Sigma-Aldrich

JKA13002

mPEG12-Propionic acid

HS-PEG1500-SH average Mn 1,500

Sigma-Aldrich

JKA4105

HS-PEG1500-SH

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

assay

>95% (HPLC)

assay

>95% (HPLC)

assay

-

assay

-

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

reaction suitability

-

reaction suitability

-

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: heterobifunctional

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: homobifunctional

shipped in

ambient

shipped in

ambient

shipped in

-

shipped in

-

特点和优势

Thiol-dPEG12-acid is a single molecular weight, discrete-length polyethylene glycol (dPEG) crosslinking PEGylation reagent. One end of the crosslinker terminates in a sulfhydryl (thiol) group. Propionic acid terminates the opposite end. The thiol end of the molecule forms dative bonds with gold. Moreover, it forms thioether bonds with maleimide and bromoacetate groups and disulfide bonds with other sulfhydryl groups. The propionic acid group reacts with amines to form amide bonds. Alternatively, if it is left unreacted, the propionic acid group provides a negative charge to the conjugated molecule or modified surface. The monodispersed dPEG spacer is 39 atoms (46.8 Å) long.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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Elizabeth R Figueroa et al.
Journal of nanobiotechnology, 14, 24-24 (2016-04-01)
Gold nanoparticles (AuNPs) have shown great promise as scaffolds for gene therapy vectors due to their attractive physiochemical properties which include biocompatibility, ease of functionalization via the nearly covalent gold-sulfur dative bond, and surface plasmon optical properties. Previously, we synthesized
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ACS omega, 3(2), 1627-1634 (2018-07-20)
The matrix metalloproteinases (MMPs) are well-known mediators that are activated in tumor progression. MMP2 is a kind of gelatinase in extracellular matrix remodeling and cancer metastasis processes. MMP2 secretion increased in many types of cancer diseases, and its abnormal expression

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