Merck

QBD10852

Sigma-Aldrich

dPEG®12-SATA (S-acetyl-dPEG®12-NHS ester)

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别名:
alpha-[2-(acetylthio)ethyl]-omega-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]poly(oxy-1,2-ethanediyl)
Empirical Formula (Hill Notation):
C33H59NO17S
分子量:
773.88
MDL编号:
PubChem化学物质编号:
NACRES:
NA.22

检测方案

>90%

形式

solid or viscous liquid

reaction suitability

reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: amine reactive

聚合物结构设计

shape: linear
functionality: monofunctional

运输

ambient

储存温度

−20°C

SMILES string

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCSC(C)=O)ON1C(CCC1=O)=O

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此商品
QBD10184QBD10181QBD10260
m-dPEG®8-NHS ester

Sigma-Aldrich

QBD10260

m-dPEG®8-NHS ester

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

reaction suitability

reagent type: chemical modification reagent, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reagent type: chemical modification reagent, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reagent type: chemical modification reagent, reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reagent type: chemical modification reagent, reagent type: cross-linking reagent
reactivity: amine reactive

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: monofunctional

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

特点和优势

dPEG®12-SATA (S-acetyl-dPEG®12-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG® linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG®12-SATA to install a protected thiol connected to the molecule via the dPEG® linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG® linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG®-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable


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