Merck
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文件

QBD10902

Sigma-Aldrich

t-Boc-N-amido-dPEG®36-acid

>95% (HPLC)

所有图片(1)
别名:
t-Boc-N-amido-PEG36-acid, t-Boc-PEG-acid, Boc-NH-PEG36-COOH, Boc-NH-PEG36-acid, BocNH-PEG1500-acid
Empirical Formula (Hill Notation):
C80H159NO40
分子量:
1775.10
MDL编号:
MFCD21363214

检测方案

>95% (HPLC)

形式

solid or viscous liquid

reaction suitability

reaction type: Pegylations

聚合物结构设计

shape: linear
functionality: heterobifunctional

运输

ambient

储存温度

−20°C

特点和优势

t-Boc-N-amido-dPEG36-acid is a monodisperse PEG product that is useful for peptide synthesis. The 112-atoms-long dPEG spacer allows the introduction of a long, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEGn-acid (n=4, 8, 12, 24, 36) product series.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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