Merck
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QBD11471

Sigma-Aldrich

MAL-dPEG®12-Tris(m-dPEG®24)3

>95% (HPLC)

所有图片(1)
别名:
Branched Maleimide-PEG-m, Branched mPEG-maleimide, MAL-NH-PEG600-Tris(mPEG1000)3, MAL-PEG12-Tris(m-PEG24)3
Empirical Formula (Hill Notation):
C194H378N6O94
分子量:
4299.06

检测方案

>95% (HPLC)

形式

solid or viscous liquid

reaction suitability

reaction type: Pegylations

聚合物结构设计

functionality: monofunctional

运输

ambient

储存温度

−20°C

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此商品
QBD11487QBD11451QBD11094
MAL-dPEG®12-Tris(m-dPEG®24)3 >95% (HPLC)

Sigma-Aldrich

QBD11471

MAL-dPEG®12-Tris(m-dPEG®24)3

MAL-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3 >95% (HPLC)

Sigma-Aldrich

QBD11487

MAL-dPEG®24-Tris(-dPEG®24-Tris(m-dPEG®24)3)3

MAL-dPEG®12-Tris(-dPEG®24-acid)3 >90% (HPLC)

Sigma-Aldrich

QBD11451

MAL-dPEG®12-Tris(-dPEG®24-acid)3

m-dPEG®12-amido-dPEG®24-DSPE >95% (HPLC)

Sigma-Aldrich

QBD11094

m-dPEG®12-amido-dPEG®24-DSPE

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

form

solid or viscous liquid

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

reaction suitability

reaction type: Pegylations

polymer architecture

functionality: monofunctional

polymer architecture

functionality: monofunctional

polymer architecture

functionality: monofunctional

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

特点和优势

MAL-dPEG12-Tris(m-dPEG24)3 is a thiol-reactive, methyl-terminated, four-arm monodispersed PEG product designed to modulate biodistribution of conjugates. Tris forms the core of the molecule. Three equal-length methyl-terminated long arms plus one maleimido-terminated short arm extend from the tris core. From the maleimido olefin to the terminal methyl groups on each arm, the end-to-end length of this product is 127 atoms with an average distance of 103.7 Å. The amphiphilic PEG imparts hydrophilicity to conjugates, reduces or eliminates the conjugates′ antigenicity, and increases the hydrodynamic volume of conjugated molecules. Applications for this product include eradicating renal clearance, maintaining in vivo circulation for more extended periods, and suppressing immune responses to conjugates.

法律信息

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

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Haiming Ding et al.
Bioconjugate chemistry, 24(11), 1945-1954 (2013-11-02)
The tumor-associated glycoprotein-72 (TAG-72) antigen is highly overexpressed in various human adenocarcinomas and anti-TAG-72 monoclonal antibodies, and fragments are therefore useful as pharmaceutical targeting vectors. In this study, we investigated the effects of site-specific PEGylation with MW 2-4 kDa discrete

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