700016P

Avanti

胆固醇硫酸盐

cholesterol 3-sulfate (sodium salt), powder

别名:
胆固醇磺酸盐;胆固醇硫酸酯;胆甾醇硫酸钠;胆固醇硫酸酯
Empirical Formula (Hill Notation):
C27H45NaO4S
CAS号:
分子量:
488.70
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (700016P-1g)
pkg of 1 × 25 mg (700016P-25mg)
pkg of 1 × 500 mg (700016P-500mg)

mfr. no.

Avanti Polar Lipids, 700016P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C27H46O4S.Na/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(31-32(28,29)30)13-15-26(20,4)25(22)14-16-27(23,24)5;/h9,18-19,21-25H,6-8,10-17H2,1-5H3,(H,28,29,30);/q;+1/p-1/t19-,21+,22+,23-,24+,25+,26+,27-;/m1./s1

InChI key

LMPVQXVJTZWENW-KPNWGBFJSA-M

General description

胆固醇硫酸酯是在胆固醇硫转移酶存在下,由胆固醇的硫酸结合作用而合成的。它可存在于大脑、肺、头发和皮肤组织以及红细胞、血小板和精子等细胞中。

Application

胆固醇硫酸酯已被用于制备胶束以及表面等离子体共振(SPR)研究。

Biochem/physiol Actions

胆固醇硫酸酯与动脉粥样硬化病变有关,可作为血小板粘附的一种基质。它可稳定精子膜和红细胞。胆固醇硫酸酯可参与到角质细胞的分化,并在隐性X连锁鱼鳞病中水平上升。它可作为视黄酸相关孤儿受体α(RORα)的一种配体。胆固醇硫酸酯可调节葡萄糖代谢,是代谢紊乱的一个潜在靶点。它还是人类宫颈癌组织和前列腺癌的一种潜在标志物。

Packaging

20 mL 透明玻璃螺旋盖小瓶(700016P-500mg)
5 mL 琥珀色玻璃螺旋盖小瓶 (700016P-25mg)
20 mL 透明玻璃螺旋盖小瓶(700016P-1g)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Charles A Strott et al.
Journal of lipid research, 44(7), 1268-1278 (2003-05-06)
Cholesterol sulfate is quantitatively the most important known sterol sulfate in human plasma, where it is present in a concentration that overlaps that of the other abundant circulating steroid sulfate, dehydroepiandrosterone (DHEA) sulfate. Although these sulfolipids have similar production and...
Patrizia Lopalco et al.
Frontiers in physiology, 10, 1344-1344 (2019-11-19)
The reduction of sperm motility and count, or oligoasthenozoospermia, is one of the major causes of reduced fertility or infertility in men. Lipid composition of spermatozoa is important in determining their functional characteristics, in particular on motility, acrosomal exocytosis or...
Xiongjie Shi et al.
Molecular and cellular biology, 34(3), 485-497 (2013-11-28)
Sulfotransferase (SULT)-mediated sulfation represents a critical mechanism in regulating the chemical and functional homeostasis of endogenous and exogenous molecules. The cholesterol sulfotransferase SULT2B1b catalyzes the sulfoconjugation of cholesterol to synthesize cholesterol sulfate (CS). In this study, we showed that the...
M Merten et al.
Circulation, 103(16), 2032-2034 (2001-04-25)
Cholesterol 3-sulfate is present on a variety of cells and in human LDL, and it has been found in atherosclerotic lesions of human aorta. Its precise biological role has not yet been described. In this study, we investigated the interaction...
Alexey V Kostarnoy et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(13), E2758-E2765 (2017-03-16)
Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation;...

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