790404P

Avanti

18:1 DGS-NTA(Ni)

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt), powder

别名:
1,2-二-(9Z-十八烯酰基)-sn-甘油-3-[(N-(5-氨基-1-羧基戊基)亚氨基二乙酸)琥珀酰基](镍盐);狗NTA
Empirical Formula (Hill Notation):
C53H93N2O15Ni
CAS号:
分子量:
1057.00
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (790404P-10mg)
pkg of 1 × 25 mg (790404P-25mg)
pkg of 1 × 5 mg (790404P-5mg)

mfr. no.

Avanti Polar Lipids, 790404P

shipped in

dry ice

storage temp.

−20°C

General description

1,2-二油酰基-sn-甘油基-3-[(N-(5-氨基-1-羧基戊基)亚氨基二乙酸)琥珀酰基]氮川三乙酸(NTA)(18:1 DGS-NTA(Ni))是含镍的共轭磷脂 。NTA与镍离子中存在六个配位点中的四个螯合。

Application

1,2-二油酰基-sn-甘油基-3-[(N-(5-氨基-1-羧基戊基)亚氨基二乙酸)琥珀酰基](镍盐)(18:1 DGS-NTA(Ni))用于:
  • 制备含卟啉-磷脂(PoP)偶联物的脂质体,用于蛋白质和肽的结合研究
  • 制备纳米级多层囊泡(NMV),用于抗原递送研究
  • 作为小单层囊泡(SUV)成分,用于制备平面脂质膜(PM)

Biochem/physiol Actions

1,2-二油酰基-sn-甘油基-3-[(N-(5-氨基-1-羧基戊基)亚氨基二乙酸)琥珀酰基]氮川三乙酸(NTA)(18:1 DGS-NTA(Ni))可用于结构生物学,尤其适合重组组氨酸标签结合蛋白。 虽然用处很大,但纳米颗粒在生物样品中存在稳定性问题。因此,NTA-脂质缀合物主要用作脂质体或纳米颗粒涂层。基于DGS-NTA(Ni)的纳米级多层囊泡(NMV)是有效的疫苗递送系统。

Packaging

5 mL透明玻璃密封安瓿(790404P-25mg)

RIDADR

NONH for all modes of transport

分析证书
原产地证书 (CofO)
Priyanka D Abeyrathne et al.
Methods in enzymology, 481, 25-43 (2010-10-05)
Electron crystallography is a powerful technique for the structure determination of membrane proteins as well as soluble proteins. Sample preparation for 2D membrane protein crystals is a crucial step, as proteins have to be prepared for electron microscopy at close...
Samuel A Merrill et al.
The Journal of biological chemistry, 285(46), 35428-35438 (2010-09-02)
VPS4 proteins are AAA(+) ATPases required to form multivesicular bodies, release viral particles, and complete cytokinesis. They act by disassembling ESCRT-III heteropolymers during or after their proposed function in membrane scission. Here we show that purified human VPS4A is essentially...
David J Montefusco et al.
Methods in enzymology, 423, 267-298 (2007-07-05)
The reconstitution of membrane-associated protein complexes poses significant experimental challenges. The core signaling complex in the bacterial chemotaxis system is an illustrative example: The soluble cytoplasmic signaling proteins CheW and CheA bind to heterogeneous clusters of transmembrane receptor proteins, resulting...
Kelly A Dryden et al.
Protein science : a publication of the Protein Society, 18(12), 2629-2635 (2009-10-22)
Bacterial microcompartments (BMCs) are large intracellular bodies that serve as simple organelles in many bacteria. They are proteinaceous structures composed of key enzymes encapsulated by a polyhedral protein shell. In previous studies, the organization of these large shells has been...
John Monsey et al.
The Journal of biological chemistry, 285(10), 7035-7044 (2009-12-22)
Her4 (ErbB-4) and Her2/neu (ErbB-2) are receptor-tyrosine kinases belonging to the epidermal growth factor receptor (EGFR) family. Crystal structures of EGFR and Her4 kinase domains demonstrate kinase dimerization and activation through an allosteric mechanism. The kinase domains form an asymmetric...

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