791275P

Avanti

18:0 PE-DTPA (Gd)

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt), powder

别名:
1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt); DSPE-DTPA (Gd)
Empirical Formula (Hill Notation):
C55H106GdN6O17P
分子量:
1311.68
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (791275P-5mg)

mfr. no.

Avanti Polar Lipids, 791275P

shipped in

dry ice

storage temp.

−20°C

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) are sparing soluble in alcohol and well soluble in a solvent mixture consisting of chloroform and methanol in the ratio of 4:1, v/v. 18:0 PE-DTPA (Gd) is a synthetic phospholipid derivative ethanolamine. The DTPA is attached to gadolinium ion.

Application

18:0 PE-DTPA (Gd) has been used:
  • as a component of Gadolinium-liposome preparation
  • in the nanodics preparation for nuclear magnetic resonance (NMR) studies
  • in construction of cysteine-arginine-glutamic acid-lysine alanine (CREKA) based peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) studies
  • as a spin-labeled lipid for supported lipid bilayer incorporation for cryo transmission electron microscopy studies

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) phospholipid based liposomes are useful in magnetic resonance imaging (MRI) and multimodal imaging. Apart from being a MRI contrast agent, PE-DTPA (Gd) liposome is also flexible for modification for binding different targets using copper–free click–chemistry methodology.

Packaging

5 mL Amber Glass Screw Cap Vial (791275P-5mg)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

分析证书
原产地证书 (CofO)
Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications
Vavra J, et al.
Advances in Functional Materials, 28(45), 1803406-1803406 (2018)
Fibrin-targeting, peptide amphiphile micelles as contrast agents for molecular MRI
Chung EJ, et al.
journal of Cell Science & Therapy, 5(5), 1-1 (2014)
Pavlína Šimečková et al.
Scientific reports, 10(1), 4780-4780 (2020-03-18)
Gadolinium (Gd)-based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier-based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes with Gd-complexes (Gd-lip) co-encapsulated with thrombolytic agents can serve both for imaging and...
Zhenhao Fang et al.
Cell chemical biology, 25(11), 1327-1336 (2018-08-21)
KRAS is frequently mutated in several of the most lethal types of cancer; however, the KRAS protein has proven a challenging drug target. K-RAS4B must be localized to the plasma membrane by prenylation to activate oncogenic signaling, thus we endeavored...
Jin Young Kang et al.
Immunity, 31(6), 873-884 (2009-11-26)
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA...

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。