810154P

Avanti

16:0-12:0 NBD PE

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphoethanolamine, powder

Empirical Formula (Hill Notation):
C39H68N5O11P
CAS号:
分子量:
813.96
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810154P-1mg)
pkg of 5 × 1 mg (810154P-5mg)

mfr. no.

Avanti Polar Lipids, 810154P

shipped in

dry ice

storage temp.

−20°C

General description

N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) is a fluorescent probe localized at the membrane interface. It possess fluorescent NBD label attached to the headgroup of phosphatidylethanolamine (PE). PE is the parent compound for phosphatidylcholine and phosphatidylethanolamine synthesis and is mostly enriched in brain.

Application

16:0-12:0 NBD PE has been used in lipid extraction assay and in vitro phospholipid fluorescence resonance energy transfer (FRET) assays. It is suitable for the determination of enzyme substrate specificity of lipoteichoic acid synthase (LtaS).

Biochem/physiol Actions

Phosphoethanolamine (PE) plays a vital role in the prevention of tumor proliferation. N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) monitors the Red edge excitation shift (REES) phenomenon with the unique motional and dielectric properties it possesses.

Packaging

5 mL Amber Glass Screw Cap Vial (810154P-1mg)
5 mL Amber Glass Screw Cap Vial (810154P-5mg)

RIDADR

NONH for all modes of transport

分析证书
原产地证书 (CofO)
Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity
Lorenzo VP, et al.
Journal of Chemistry, 2016 (2016)
Application of NBD-labeled lipids in membrane and cell biology
Fluorescent methods to study biological membranes, 37-50 (2012)
María Isabel Hernández-Alvarez et al.
Cell, 177(4), 881-895 (2019-05-06)
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
Ouma Onguka et al.
The Journal of biological chemistry, 290(20), 12744-12752 (2015-04-02)
Phosphatidylethanolamine (PE) is a major cellular phospholipid that can be made by four separate pathways, one of which resides in the mitochondrion. The mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p). The pool of PE produced by Psd1p...
S C Lopes et al.
Biochimica et biophysica acta. Biomembranes, 1861(6), 1152-1161 (2019-03-07)
Mitochondrial membranes are pointed out as the site of cardiotoxic action of local anaesthetics. Its three main phospholipids components are phosphatidylcholine, phosphatidylethanolamine and cardiolipin. Cardiolipins, in eukaryotes, are only found in mitochondria and are essential for the maintenance of its...

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