810185P

Avanti

TopFluor® PI(4)P

1-oleoyl-2-{6-4-(dipyrrometheneboron difluoride)butanoylamino}hexanoyl-sn-glycero-3-phosphoinositol-4-phosphate (ammonium salt), powder

Empirical Formula (Hill Notation):
C50H88BF2N5O17P2
CAS号:
分子量:
1142.01
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 50 μg (with stopper and crimp cap (810185P-50ug))

mfr. no.

Avanti Polar Lipids, 810185P

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylinositol 4-phosphate (PI4P) is a precursor of phosphatidylinositol (4,5)-bisphosphate PI(4,5)P2. It is present in the membranes of Golgi apparatus.

Application

TopFluor® PI(4)P has been used as fluorescently labeled phosphoinositide to examine phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN) interaction with anionic lipids.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (810185P-50ug)

Legal Information

TopFluor is a registered trademark of Avanti Polar Lipids, Inc.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

分析证书
原产地证书 (CofO)
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 77, 125-135 (2015)
Xiaojun Shi et al.
Langmuir : the ACS journal of surfaces and colloids, 32(7), 1732-1741 (2016-02-02)
Phosphatidylinositol phosphate (PIP) lipids are critical to many cell signaling pathways, in part by acting as molecular beacons that recruit peripheral membrane proteins to specific locations within the plasma membrane. Understanding the biophysics of PIP-protein interactions is critical to developing...
PI4P and PI (4, 5) P2 are essential but independent lipid determinants of membrane identity
Hammond GRV, et al.
Science, 337(6095), 727-730 (2012)

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