810211C

Avanti

C12-NBD Ceramide

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-erythro-sphingosine, chloroform

Empirical Formula (Hill Notation):
C36H61N5O6
CAS号:
分子量:
659.90
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

packaging

pkg of 1 × 1 mL (810211C-1mg)

mfr. no.

Avanti Polar Lipids, 810211C

concentration

1 mg/mL (810211C-1mg)

shipped in

dry ice

storage temp.

−20°C

Application

C12-NBD ceramide is suitable for its use:
  • as a substrate to measure the activity of acid, alkaline and neutral ceramidases
  • in in vitro ceramidase activity assay
  • in ceramide phosphoethanolamine (CPE) synthase assay to determine the Km and Vmax of sphingomyelin synthase (SMS1, SMS2, and SMSr)

Biochem/physiol Actions

Ceramide is one of the products of sphingolipid metabolism. The members of ceramide synthase family are responsible for its synthesis. Each ceramide synthesized differs in its acyl chain length. Ceramides possess a wide range of functions, associated with apoptosis, cancer inhibition and chemotherapy. Its action is also related to neurodegenerative diseases.

Packaging

5 mL Amber Glass Screw Cap Vial (810211C-1mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Target Organs

Central nervous system

RIDADR

UN 1888 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

分析证书
原产地证书 (CofO)
A Critical Role for Ceramide Synthase 2 in Liver Homeostasis I. ALTERATIONS IN LIPID METABOLIC PATHWAYS
Pewzner JY, et al.
The Journal of Biological Chemistry, 285(14), 10902-10910 (2010)
The ATP-binding cassette transporter-2 (ABCA2) overexpression modulates sphingosine levels and transcription of the amyloid precursor protein (APP) gene
Davis W
Current Alzheimer Research, 12(9), 847-859 (2015)
All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity
Ding T, et al.
Journal of Lipid Research, 56(3), 537-545 (2015)
Mammalian ceramide synthases
Levy M and Futerman AH
IUBMB Life, 62(5), 347-356 (2010)
Li-Yu Chen et al.
Nature communications, 6, 6030-6030 (2015-01-17)
Turgor pressure plays pivotal roles in the growth and movement of walled cells that make up plants and fungi. However, the molecular mechanisms regulating turgor pressure and the coordination between turgor pressure and cell wall remodelling for cell growth remain...

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