810221P

Avanti

C12-NBD Galactosyl Ceramide

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-D-galactosyl-β1-1′-sphingosine, powder

Empirical Formula (Hill Notation):
C42H71N5O11
CAS号:
分子量:
822.04
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 250 μg (810221P-250ug)

mfr. no.

Avanti Polar Lipids, 810221P

shipped in

dry ice

storage temp.

−20°C

General description

C12-NBD Galactosyl Ceramide is a fluorescent derivative of biologically active compound galactosyl ceramide. NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) is a fluorophore. Galactosyl ceramide (Galactocerebroside) is a glycosphingolipid that is synthesized in the lumen of the endoplasmic reticulum.

Application

C12-NBD Galactosyl Ceramide may be used as a substrate in biochemical characterization of ceramidase analogue expressed in Aspergillus oryzae.

Biochem/physiol Actions

Galactosyl Ceramide is a precursor of 3′-sulfo-galactosylceramide which is a major sulfoglycolipid present in the brain and other organ systems. It is also a necessary component in differentiation of oligodendrocytes. The abnormal accumulation of galactosyl ceramide is associated with Fabry′s disease and Krabbe′s disease.

Packaging

5 mL Amber Glass Screw Cap Vial (810221P-250ug)

RIDADR

NONH for all modes of transport

分析证书
原产地证书 (CofO)
Characterization of a neutral ceramidase orthologue from Aspergillus oryzae
Fluorescent and Luminescent Probes for Biological Activity, 298(2), 157-165 (1999)
Heike Schulze et al.
Cold Spring Harbor perspectives in biology, 3(6) (2011-04-20)
Lysosomal lipid storage diseases, or lipidoses, are inherited metabolic disorders in which typically lipids accumulate in cells and tissues. Complex lipids, such as glycosphingolipids, are constitutively degraded within the endolysosomal system by soluble hydrolytic enzymes with the help of lipid...
Yanfeng Chen et al.
Neuromolecular medicine, 12(4), 306-319 (2010-08-04)
Sphingolipids (SP) are a complex class of molecules found in essentially all eukaryotes and some prokaryotes and viruses where they influence membrane structure, intracellular signaling, and interactions with the extracellular environment. Because of the combinatorial nature of their biosynthesis, there...
Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture.
M C Raff et al.
Nature, 274(5673), 813-816 (1978-08-24)

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