810262P

Avanti

C11 TopFluor® Ceramide

N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine, powder

别名:
N-[11-(TopFluor)undecanoyl]-D-erythro-sphingosine
Empirical Formula (Hill Notation):
C42H70N3O3F2
CAS号:
分子量:
703.02
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 250 μg (810262P-250ug)

mfr. no.

Avanti Polar Lipids, 810262P

shipped in

dry ice

storage temp.

−20°C

General description

Ceramide, a bioactive sphingolipid belongs to the sphingolipid family of cell lipids. This pore-forming member is insoluble in water. It is a hygroscopic and light sensitive lipid.

Application

C11 TopFluor® Ceramide may be used:
  • in the ceramide and B-cell lymphoma-extra-large (Bcl-xL) binding studies to study the effect on ceramide channel formation
  • as a tracer in confocal microscopy to treat T84 cells in order to study its localization in sphingomyelinase (SMase)-induced F-actin structures
  • to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy

Biochem/physiol Actions

Ceramide is known to participate in apoptosis, mediated by mitochondria. Ceramide channels plays a key role in the onset of apoptosis in vivo.

Packaging

5 mL Amber Glass Screw Cap Vial (810262P-250ug)

Legal Information

TopFluor is a registered trademark of Avanti Polar Lipids, Inc.

RIDADR

NONH for all modes of transport

分析证书
原产地证书 (CofO)
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Saslowsky DE, et al.
Molecular Biology of the Cell, 27(7), 1120-1130 (2016)
Ceramide Channels: Destabilization by Bcl-xL and Role in Apoptosis
Chang KT, et al.
Biochimica et Biophysica Acta, 1848(10 0 0), 2374-2374 (2015)
Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility
Kuc N, et al.
Biochemical Pharmacology, 156, 458-466 (2018)

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