810264P

Avanti

C11 TopFluor® Phytosphingosine

N-11-(dipyrrometheneboron difluoride)undecanoyl-phytosphingosine, powder

别名:
N-11-(TopFluor)undecanoyl-phytosphingosine
Empirical Formula (Hill Notation):
C42H72N3O4F2
CAS号:
分子量:
721.04
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 250 μg (810264P-250ug)

mfr. no.

Avanti Polar Lipids, 810264P

shipped in

dry ice

storage temp.

−20°C

General description

Phytosphingosine is a glycolipid component, present in the intestine of vertebrates. It belongs to the class of sphingolipids. It is seen at high level in plants and fungi. Phytosphingosine is also abundantly present in the epidermis of mammals.

Biochem/physiol Actions

Phytosphingosine helps to protect the skin by preventing the loss of its moisture. It plays a key role in the epidermal cell growth, differentiation and cell death. Phytosphingosine exhibits bactericidal and anti-inflammatory properties. Phytosphingosine modulates the synthesis of lipid in the epidermal stratum corneum. It is capable of blocking nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling. Phytosphingosine is known to participate in the differentiation of keratinocytes.

Packaging

5 mL Amber Glass Screw Cap Vial (810264P-250ug)

Legal Information

TopFluor is a registered trademark of Avanti Polar Lipids, Inc.

RIDADR

NONH for all modes of transport

分析证书
原产地证书 (CofO)
Phytosphingosine is a characteristic component of the glycolipids in the vertebrate intestine.
Nishimura K
Comparative Biochemistry and Physiology. B, Comparative Biochemistry, 86(1), 149-154 (1987)
Analysis of skin penetration of phytosphingosine by fluorescence detection and influence of the thermotropic behaviour of DPPC liposomes
Hasanovic A, et al.
International Journal of Pharmaceutics, 383(1), 14-17 (2010)
Byung-Hak Kim et al.
The Journal of investigative dermatology, 134(4), 1023-1032 (2013-11-02)
Phytosphingosine is abundant in plants and fungi and is found in mammalian epidermis, including the stratum corneum. Phytosphingosine and its derivatives N-acetyl phytosphingosine and tetraacetyl phytosphingosine are part of the natural defense system of the body. However, these molecules exhibit...

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