810340P

Avanti

Click PI(4,5)P2-azido

1-oleoyl-2-(6-(6-azidohexanoyl)aminohexanoyl)-sn-glycero-3-phosphoinositol-4.5-bisphosphate (ammonium salt), powder

Empirical Formula (Hill Notation):
C39H82N7O20P3
CAS号:
分子量:
1062.02
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (810340P-100ug))

mfr. no.

Avanti Polar Lipids, 810340P

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is an anionic lipid  and is present in the plasma membrane (PM).

Biochem/physiol Actions

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a lipid messenger. It controls exocytosis, actin cytoskeleton dynamics and endocytosis. It also plays a key role in signal transduction, vesicle trafficking and motility. The azido functional group in the lipid may involve in a copper-catalyzed reaction to form click reaction.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (810340P-100ug)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

分析证书
原产地证书 (CofO)
Xiaojun Tan et al.
Journal of cell science, 128(22), 4047-4056 (2015-11-18)
Phosphoinositides are a collection of lipid messengers that regulate most subcellular processes. Amongst the seven phosphoinositide species, the roles for phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] at the plasma membrane, such as in endocytosis, exocytosis, actin polymerization and focal adhesion assembly, have been...
Clickable lipids: azido and alkynyl fatty acids and triacylglycerols
Zerkowski JA, et al.
Journal of the American Oil Chemists' Society, 86(11), 1115-1115 (2009)
Analysis of Phosphatidic Acid Binding and Regulation of PIPKI In Vitro and in Intact Cells
Methods in Enzymology, 583, 359-374 (2017)
Arne Gericke et al.
Advances in experimental medicine and biology, 991, 85-104 (2013-06-19)
PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) is a relatively common anionic lipid that regulates cellular functions by multiple mechanisms. Hydrolysis of PtdIns(4,5)P2 by phospholipase C yields inositol trisphosphate and diacylglycerol. Phosphorylation by phosphoinositide 3-kinase yields PtdIns(3,4,5)P3, which is a potent signal for survival...
Mira Sohn et al.
The Journal of cell biology, 217(5), 1797-1813 (2018-02-24)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a critically important regulatory lipid of the plasma membrane (PM); however, little is known about how cells regulate PM PI(4,5)P2 levels. Here, we show that the phosphatidylinositol 4-phosphate (PI4P)/phosphatidylserine (PS) transfer activity of the endoplasmic reticulum...

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