841188P

Avanti

E. coli PG

L-α-phosphatidylglycerol (E. coli) (sodium salt), powder

CAS号:
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (841188P-10mg)
pkg of 1 × 25 mg (841188P-25mg)

mfr. no.

Avanti Polar Lipids, 841188P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC(O)CO)=O)(OC(CCCCCCCC(C1)C1CCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[Na+]

General description

Phosphatidylglycerol (PG) is a membrane lipid found in the inner membrane of E. coli.

Application

E. coli PG or L-α-phosphatidylglycerol (E. coli) (sodium salt) might be used:
  • as a lipid antigen to trigger human T cell response
  • as a standard in mass spectrometry (MS) of mammalian cell entry (MCE) proteins bound to phosphatidylglycerol (PG)
  • in bacterial model membranes to evaluate the lipid-lipid interactions and to serve potentially as a model for validation of novel

Packaging

5 mL Clear Glass Sealed Ampule (841188P-10mg)
5 mL Clear Glass Sealed Ampule (841188P-25mg)

RIDADR

NONH for all modes of transport

Adam Shahine et al.
Science immunology, 2(16) (2017-10-22)
Human T cell autoreactivity toward lipid antigens presented by CD1 proteins can manifest in numerous diseases, including psoriasis, contact hypersensitivities, and allergies. However, the molecular mechanisms for regulating T cell autoreactivity toward lipid antigens remain unclear. We determined the basis...
Damian C Ekiert et al.
Cell, 169(2), 273-285 (2017-04-08)
How phospholipids are trafficked between the bacterial inner and outer membranes through the hydrophilic space of the periplasm is not known. We report that members of the mammalian cell entry (MCE) protein family form hexameric assemblies with a central channel...
Mikhail Bogdanov et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(34), 15057-15062 (2010-08-11)
Phosphatidylcholine (PC) has been widely used in place of naturally occurring phosphatidylethanolamine (PE) in reconstitution of bacterial membrane proteins. However, PC does not support native structure or function for several reconstituted transport proteins. Lactose permease (LacY) of Escherichia coli, when...
Javier Hoyo et al.
General physiology and biophysics, 39(2), 195-202 (2020-04-25)
The current strategies to eradicate bacteria require that the antimicrobial agent either penetrate or disrupt the bacterial membrane. In Escherichia coli (E.coli) as a model of Gram-negative strains, the antimicrobials have to cross two barriers - the outer and the...
Ildiko Van Rhijn et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(2), 380-385 (2015-12-02)
In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have been difficult to isolate in humans. Here we report the development of polyvalent complexes of CD1b proteins and...

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