850155P

Avanti

18:1 PI(4,5)P2

1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt), powder

别名:
1,2-二-(9Z十八烯酰基)-sn-甘油-3-磷酸肌醇-4,5-二磷酸(铵盐);PIP24′,5′(18:1(9Z)/18:1(9Z))
Empirical Formula (Hill Notation):
C45H94N3O19P3
CAS号:
分子量:
1074.16
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850155P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850155P-500ug))

mfr. no.

Avanti Polar Lipids, 850155P

shipped in

dry ice

storage temp.

−20°C

SMILES string

HC@@(COP(O-)(OC@H1C@H(O)C@@H(OP(O)(O-)=O)C@H(OP(O-)(O)=O)C@@H(O)C@H1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.NH4+.NH4+.NH4+

General description

尽管PI(4,5)P2是细胞膜的微量组成成分,但它作为许多重要信号蛋白的底物起着关键作用。PI(4,5)P2是IP3/DAG途径中的中间体,其中它被磷脂酶C水解以释放第二信使,肌醇-1,4,5-三磷酸(IP3)和二酰基甘油(DAG)。PI(4,5)P2也是PI 3-激酶的底物,其可被磷酸化为PI(3,4,5)P3,从而作为下游信号组分,例如蛋白激酶AKT的激活剂。
磷脂酰肌醇是一种结构性磷脂。磷脂酰肌醇磷酸(PIP)位于质膜中。

Application

18:1 PI(4,5)P2可用作天然巨噬细胞膜的添加剂,以生成富含磷脂的膜脂质体。它还可用于:
  • 制备阴离子磷脂脂质体
  • 作为支撑膜管 (SMrT) 模板的成分
  • 用于脂质体制备

Biochem/physiol Actions

磷脂酰肌醇二磷酸盐 (PIP2) 可以有效地刺激ATP酶。

Packaging

带塞子和压接盖的2 mL琥珀色精华瓶(850155P-100ug)
带塞子和压接盖的2 mL琥珀色精华瓶(850155P-500ug)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Phosphatidylinositol Turnover and Receptors
Ramazzotti G, et al.
Archives of Biochemistry and Biophysics (2016)
Tripartite Chimeras Comprising Functional Domains Derived from the Cytosolic NADPH Oxidase Components p47phox, p67phox, and Rac1 Elicit Activator-independent Superoxide Production by Phagocyte Membranes AN ESSENTIAL ROLE FOR ANIONIC MEMBRANE PHOSPHOLIPIDS
Berdichevsky Y, et al.
The Journal of biological chemistry, 282(30), 22122- 22139 (2007)
Dissociation of Rac1 (GDP)-RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3, 4, 5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP
Ugolev Y, et al.
The Journal of Biological Chemistry, 283(32), 22257-22271 (2008)
Phosphatidylinositol phosphate, phosphatidylinositol bisphosphate, and the phosphoinositol sphingolipids are found in the plasma membrane and stimulate the plasma membrane H+-ATPase of Saccharomyces cerevisiae
Patton JL and Lester RL
Archives of Biochemistry and Biophysics, 292(1), 70-76 (1992)
Use of the supported membrane tube assay system for real time analysis of membrane fission reactions
Dar S, et al.
Nature Protocols, 12(2), 390-390 (2017)

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