850366P

Avanti

18:0 (9,10dibromo) PC

1,2-di-(9,10-dibromo)stearoyl-sn-glycero-3-phosphocholine, powder

别名:
1,2-di-(9,10-dibromooctadecanoyl)-sn-glycero-3-phosphocholine
Empirical Formula (Hill Notation):
C44H84NO8PBr4
CAS号:
分子量:
1105.73
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (850366P-10mg)

mfr. no.

Avanti Polar Lipids, 850366P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(Br)C(Br)CCCCCCCC)=O)COC(CCCCCCCC(Br)C(Br)CCCCCCCC)=O)=O

General description

18:0 (9,10dibromo) PC (1,2-di-(9,10-dibromo)stearoyl-sn-glycero-3-phosphocholine) is a zwitterionic and brominated phospholipid.

Application

18:0 (9,10dibromo) PC (1,2-di-(9,10-dibromo)stearoyl-sn-glycero-3-phosphocholine) may be used:
  • in the preparation of liposomes/small unilamellar vesicles (SUVs)
  • in the preparation of large unilamellar vesicles (LUVs) to facilitate vesicles sedimentation
  • as a component in liposomes

Biochem/physiol Actions

Phosphatidylcholine (PC) serves as a surfactant to prevent the penetrance of bacteria. Brominated lipids are capable of recognizing the lipid binding sites on the surface of the reaction center from Rhodobacter sphaeroides.

Packaging

5 mL Clear Glass Sealed Ampule (850366P-10mg)

RIDADR

NONH for all modes of transport

Aleksander W Roszak et al.
Biochemistry, 46(11), 2909-2916 (2007-02-24)
This study describes the use of brominated phospholipids to distinguish between lipid and detergent binding sites on the surface of a typical alpha-helical membrane protein. Reaction centers isolated from Rhodobacter sphaeroides were cocrystallized with added brominated phospholipids. X-ray structural analysis...
Olatz Landeta et al.
The Journal of biological chemistry, 286(10), 8213-8230 (2011-01-05)
BAK is a key effector of mitochondrial outer membrane permeabilization (MOMP) whose molecular mechanism of action remains to be fully dissected in intact cells, mainly due to the inherent complexity of the intracellular apoptotic machinery. Here we show that the...
Inflammatory Bowel Disease
Integrative Medicine, 501-516 (2018)
Jocelyn Méré et al.
The Biochemical journal, 386(Pt 1), 47-56 (2004-11-06)
Gelsolin is a calcium-, pH- and lipid-dependent actin filament severing/capping protein whose main function is to regulate the assembly state of the actin cytoskeleton. Gelsolin is associated with membranes in cells, and it is generally assumed that this interaction is...
Maria Jesús Sánchez-Martín et al.
Journal of colloid and interface science, 360(1), 124-131 (2011-05-14)
The aim of this study was to identify proteins that could inhibit the activity of the peptide sequence representing the N-terminal of the surface protein gp41 of HIV, corresponding to the fusion peptide of the virus (HIV-1 FP). To do...

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