850755C

Avanti

18:2 PE

1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine, chloroform

别名:
1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine; PE(18:2(9Z,12Z)/18:2(9Z,12Z))
Empirical Formula (Hill Notation):
C41H74NO8P
CAS号:
分子量:
740.00
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

packaging

pkg of 1 × 2.5 mL (850755C-25mg)
pkg of 2 × 4 mL (850755C-200mg)

mfr. no.

Avanti Polar Lipids, 850755C

concentration

10 mg/mL (850755C-25mg)
25 mg/mL (850755C-200mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

HC@@(COP(O-)(OCCNH3+)=O)(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\C/C=C\CCCCC)=O

General description

Phosphatidylethanolamine (PE) is the second most plenteous glycerophospholipid in eukaryotic cells. It is a non-bilayer forming phospholipid, which is found majorly in the mitochondria. It consists of a small polar head group with fatty acid chains.

Application

18:2 PE has been used for the preparation of liposomes.

Biochem/physiol Actions

Phosphatidylethanolamine (PE) functions as to provide rigidity to the cell membranes via hexagonal phase structures which promote tight packing of the membrane bilayer formed by phosphatidylcholine. It is also involved in the conversion of prions from the non-toxic to toxic conformation. PE also initiates the autophagosome formation by attaching covalently to the autophagy Atg8 protein.

Packaging

5 mL Clear Glass Sealed Ampule (850755C-200mg)
5 mL Clear Glass Sealed Ampule (850755C-25mg)

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Target Organs

Central nervous system

RIDADR

UN 1888 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Phosphatidylethanolamine metabolism in health and disease
International Review of Cell and Molecular Biology, 321, 29-88 (2016)
Ethanolamine and Phosphatidylethanolamine Partners in Health and Disease
Patel D and Witt SN
Oxidative Medicine and Cellular Longevity, 2017, 29-88 (2017)
Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage
Manni M M, et al.
eLife, 7, e34394-e34394 (2018)

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