Hiroyasu Sato et al.
Cell reports, 31(5), 107579-107579 (2020-05-07)
Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase...
Poorna C R Yalagala et al.
Molecular nutrition & food research, 64(12), e2000059-e2000059 (2020-04-19)
Currently available omega-3 fatty acid supplements do not enrich the docosahexaenoic acid (DHA) of the adult brain because they are absorbed as triacylglycerol, whereas the transporter at the blood brain barrier requires lysophosphatidylcholine (LPC)-DHA. The hypothesis that treatment of krill...
Generation and quality control of lipidomics data for the alzheimer?s disease neuroimaging initiative cohort
Barupal DK, et al.
Scientific data, 5, 180263-180263 (2018)
Michael M Dubreuil et al.
Cell reports, 30(5), 1417-1433 (2020-02-06)
Reactive oxygen species (ROS) play critical roles in metabolism and disease, yet a comprehensive analysis of the cellular response to oxidative stress is lacking. To systematically identify regulators of oxidative stress, we conducted genome-wide Cas9/CRISPR and shRNA screens. This revealed a detailed...
Melania Gaggini et al.
International journal of molecular sciences, 20(24) (2020-01-01)
Metabolomics/lipidomics are important tools to identify novel biomarkers associated with liver damage. Patients with chronic liver disease (CLD) and hepatitis C virus (HCV) infection often have alterations in glucose, lipid and protein metabolism. The aim of this study was to...