855774C

Avanti

2-18:0 Lyso PC

2-stearoyl-sn-glycero-3-phosphocholine, chloroform

Empirical Formula (Hill Notation):
C26H54 NO7P
CAS号:
分子量:
523.68
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (TLC)

packaging

pkg of 1 × 1 mL (855774C-1mg)

mfr. no.

Avanti Polar Lipids, 855774C

concentration

1 mg/mL (855774C-1mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)CO)=O

General description

2-18:0 Lyso PC is one of the degradation products of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC).
2-18:0 Lyso PC or lyso-phosphatidylcholine (LPC) is a bioactive proinflammatory lipid produced on pathological response. It contains choline group at its polar head.

Application

2-18:0 Lyso PC may be used to study the influence of cholesterol and β-sitosterol on the structure of phosphatidylcholine bilayers. It may also be used as a reference standard for its determination in 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) formulations by a reverse-phase liquid chromatography charged aerosol detection (RPLC-CAD) technique.

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) alters several biological activities in various cell-types, including endothelial cells, smooth muscle cells, monocytes, macrophages and T-cells and leads to the development of atherosclerosis and inflammatory diseases. In addition, it also facilitates the activation of many second messengers such as, protein kinase C, extracellular-signal-regulated kinases and protein tyrosine kinases.

Packaging

5 mL Clear Glass Sealed Ampule (855774C-1mg)

RIDADR

UN 1888 6.1 / PGIII

Hydrophobic thickness, lipid surface area and polar region hydration in monounsaturated diacylphosphatidylcholine bilayers: SANS study of effects of cholesterol and beta-sitosterol in unilamellar vesicles
Gallova J, et al.
Biochimica et Biophysica Acta - Biomembranes, 1778(11), 2627-2632 (2008)
James Tam et al.
Journal of pharmaceutical and biomedical analysis, 155, 288-297 (2018-04-21)
A four parameter optimization of a stability indicating method for non-chromophoric degradation products of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1-stearoyl-sn-glycero-3-phosphocholine and 2-stearoyl-sn-glycero-3-phosphocholine was achieved using a reverse phase liquid chromatography-charged aerosol detection (RPLC-CAD) technique. Using the hydrophobic subtraction model of selectivity, a core-shell...
Analysis of phospholipid species in rat peritoneal surface layer by liquid chromatography/electrospray ionization ion-trap mass spectrometry
Gao F, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1761(7), 667-676 (2006)
Role of lysophosphatidylcholine (LPC) in atherosclerosis
Matsumoto T, et al.
Current Medicinal Chemistry, 14(30), 3209-3220 (2007)

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。