857119C

Avanti

06:0 Lyso PA

1-hexanoyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt), chloroform

别名:
1-hexanoyl-sn-glycero-3-phosphate (ammonium salt); PA(6:0/0:0)
Empirical Formula (Hill Notation):
C9H22NO7P
CAS号:
分子量:
287.25
NACRES:
NA.25
价格与库存信息目前不能提供

assay

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

packaging

pkg of 1 × 2.5 mL (857119C-25mg)

mfr. no.

Avanti Polar Lipids, 857119C

concentration

10 mg/mL (857119C-25mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC@(COP(O-)(O)=O)(H)COC(CCCCC)=O.NH4+

General description

Lysophosphatidic acid (LPA) is the major component of serum. It has a free hydroxyl and phosphate moiety. LPA is hydrophilic and is not associated with the membrane.

Application

06:0 Lyso PA has been used for the quantification of lipopolysaccharide (LPS) (endotoxin) levels in various commercial and pharmaceutical grade preparations.

Biochem/physiol Actions

Lysophosphatidic acid (LPA) acts as the precursor for the synthesis of phospholipids in eukaryotes and prokaryotes. It prevents differentiation of neuroblastoma and myoblast, supports in neurotransmitter release and smooth muscle contraction. LPA plays a vital role in tissue healing and wound regeneration. It binds to G-protein coupled receptors. LPA has mitogenic properties. It functions as an intercellular signaling molecule. LPA is involved in the initiation of neuropathic pain.

Packaging

5 mL Clear Glass Sealed Ampule (857119C-25mg)

RIDADR

UN 1888 6.1 / PGIII

Lysophosphatidic acid, a multifunctional phospholipid messenger
Moolenaar WH
The Journal of Biological Chemistry, 270(22), 12949-12952 (1995)
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
Inoue M, et al.
Nature Medicine, 10(7), 712-712 (2004)
Lysophosphatidic acid: G-protein signalling and cellular responses
Moolenaar WH, et al.
Current Opinion in Cell Biology, 9(2), 168-173 (1997)
Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors
Weinstein JR, et al.
Glia, 56(1), 16-26 (2008)
Jesica R Williams et al.
The Journal of biological chemistry, 284(25), 17304-17319 (2009-04-16)
Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. Because the structure-activity relationship (SAR) of GPR92/LPA(5) is limited and whether LPA is its...

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

社交媒体

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

科研、开发、生产。

作为生命科学行业的全球领先供应商,我们致力于为科研、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021年版权归德国达姆施塔特默克集团(Merck KGaA)及/或其附属公司所有。版权所有。

未经许可,严禁复制本网站上的任何资料。