860474P

Avanti

1-deoxysphinganine-d3

1-deoxysphinganine-d3 (m18:0), powder

Empirical Formula (Hill Notation):
C18H36D3NO
CAS号:
分子量:
288.53
NACRES:
NA.25
价格与库存信息目前不能提供

form

powder

packaging

pkg of 1 × 500 μg (860474P-500ug)

mfr. no.

Avanti Polar Lipids, 860474P

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCC@(O)(H)C@(N)(H)C(2H)(2H)2H

General description

1-deoxysphinganine-d3 is a deuterated compound, wherein the three protons of deoxysphinganine are replaced by deuterium. 1-deoxysphinganine is an atypical sphingoid base devoid of a 1-hydroxyl group.

Biochem/physiol Actions

1-deoxysphinganine acts as a biomarker for Type 2 diabetes. It can function as a cytotoxic lipid for insulin producing cells. 1-deoxysphinganine might exhibit toxicity to cancerous cells.

Packaging

5 mL Amber Glass Screw Cap Vial (860474P-500ug)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Richard A Zuellig et al.
Diabetes, 63(4), 1326-1339 (2014-01-01)
Irreversible failure of pancreatic β-cells is the main culprit in the pathophysiology of diabetes, a disease that is now a global epidemic. Recently, elevated plasma levels of deoxysphingolipids, including 1-deoxysphinganine, have been identified as a novel biomarker for the disease....
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that...

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