860569P

Avanti

C17 Glucosyl(β) Ceramide (d18:1/17:0)

D-glucosyl-β-1,1′-N-heptadecanoyl-D-erythro-sphingosine, powder

Empirical Formula (Hill Notation):
C41H79NO8
CAS号:
分子量:
714.07
NACRES:
NA.25
价格与库存信息目前不能提供

form

powder

packaging

pkg of 1 × 25 mg (860569P-25mg)
pkg of 1 × 5 mg (860569P-5mg)

mfr. no.

Avanti Polar Lipids, 860569P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O

General description

Glucosyl(β) Ceramide (β-GlcCer) is a naturally occurring glycolipid. It is also a ubiquitous intracellular metabolite.

Biochem/physiol Actions

Glucosyl(β) Ceramide (β-GlcCer) regulates the activity of natural killer T (NKT) lymphocytes and displays antimetastatic effects. It is an endogenous macrophage inducible C-type lectin (Mincle) ligand, which exhibits immunostimulatory property. β-GlcCer promotes inflammatory and acquired immune responses on myeloid cells via Mincle. It acts as a potential biomarker for Gaucher′s disease.

Packaging

5 mL Amber Glass Screw Cap Vial (860569P-5mg)
5 mL Amber Glass Screw Cap Vial (860569P-25mg)

RIDADR

NONH for all modes of transport

Masashi Inafuku et al.
Lipids, 47(6), 581-591 (2012-03-20)
Natural killer (NK) T cells are well known to play important roles in both tumor rejection and the defense against infectious. Therefore, the antitumor potential of NKT cell-activating antigens have been the focus for the development of NKT cell-based immunotherapies....
E Zigmond et al.
Gut, 56(1), 82-89 (2006-12-19)
beta-Glucosylceramide, a naturally occurring glycolipid, exerts modulatory effects on natural killer T (NKT) lymphocytes. To determine whether beta-glucosylceramide can alter NKT function in opposite directions, colitis was induced by intracolonic installation of trinitrobenzenesulphonic acid, and hepatocellular carcinoma (HCC) was induced...
Masahiro Nagata et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(16), E3285-E3294 (2017-04-05)
Sensing and reacting to tissue damage is a fundamental function of immune systems. Macrophage inducible C-type lectin (Mincle) is an activating C-type lectin receptor that senses damaged cells. Notably, Mincle also recognizes glycolipid ligands on pathogens. To elucidate endogenous glycolipids...

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