860575P

Avanti

C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0)

D-lactosyl-β1-1′-N-octanoyl-L-threo-sphingosine, powder

Empirical Formula (Hill Notation):
C38H71NO13
CAS号:
分子量:
749.97
NACRES:
NA.25
价格与库存信息目前不能提供

form

powder

packaging

pkg of 1 × 1 mg (860575P-1mg)

mfr. no.

Avanti Polar Lipids, 860575P

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCC/C=C/[C@@](O)([H])[C@@]([H])(NC(CCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O

General description

C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0) is a synthetic glycosphingolipid (GSL) with nonnatural stereochemistry.

Application

C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0) may be used to disrupt brain-derived neurotropic factor (BDNF)-induced integrin clustering.

Biochem/physiol Actions

C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0) is a caveolar uptake inhibitor, which blocks SV40 virus infection. It also prevents E1-integrin activation and downstream signaling. C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0) can deter the aggregation of lipids and proteins into glycosphingolipids (GSLs) and cholesterol-enriched microdomains (rafts) at the plasma membrane (PM).

Packaging

5 mL Amber Glass Screw Cap Vial (860575P-1mg)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Bidirectional remodeling of beta1-integrin adhesions during chemotropic regulation of nerve growth
Carlstrom LP, et al.
BMC biology, 9(1), 82-82 (2011)

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