860580P

Avanti

02:0 SM (d18:1/2:0)

N-acetyl-D-erythro-sphingosylphosphorylcholine, powder

Empirical Formula (Hill Notation):
C25H51N2O6P
CAS号:
分子量:
506.66
NACRES:
NA.25
价格与库存信息目前不能提供

form

powder

packaging

pkg of 1 × 5 mg (860580P-5mg)

mfr. no.

Avanti Polar Lipids, 860580P

shipped in

dry ice

storage temp.

−20°C

SMILES string

HC@(/C=C/CCCCCCCCCCCCC)(O)C@@(H)(NC(C)=O)COP(O-)(OCCN+(C)(C)C)=O

General description

Sphingomyelin is abundantly present in the cell membranes, particularly in myelin sheath and red blood cells. It has a ceramide unit with a phosphorylcholine moiety linked to position 1.

Application

02:0 SM (d18:1/2:0) is suitable for use in liposomes to measure ostreolysin A (OlyA) binding in order to infer the effects of phosphatidylcholines (PCs) on sphingomyelin (SM)/cholesterol interactions.

Biochem/physiol Actions

Sphingomyelin (SM) has high cholesterol affinity, which aids localization and interactions of proteins. It functions as a precursor to ceramides and other sphingolipid metabolites.

Packaging

5 mL Clear Glass Sealed Ampule (860580P-5mg)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death
Jana A, et al.
Journal of the Neurological Sciences, 278(1-2), 5-15 (2009)
Molecular discrimination between two conformations of sphingomyelin in plasma membranes
Endapally S, et al.
Cell, 176(5), 1040-1053 (2019)
Delphine Milhas et al.
FEBS letters, 584(9), 1887-1894 (2009-10-28)
The plasma membrane (PM) is a major resource for production of bioactive lipids and contains a large proportion of the cellular sphingomyelin (SM) content. Consequently, the regulation of SM levels at the PM by enzymes such as sphingomyelinase (SMase) and...

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