860626P

Avanti

C8 Dihydroceramide (d18:0/8:0)

N-octanoyl-D-erythro-sphinganine, powder

Empirical Formula (Hill Notation):
C26H53NO3
CAS号:
分子量:
427.70
NACRES:
NA.25
价格与库存信息目前不能提供

form

powder

packaging

pkg of 1 × 5 mg (860626P-5mg)

mfr. no.

Avanti Polar Lipids, 860626P

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

Application

C8 Dihydroceramide (d18:0/8:0) has been used as an internal standard to quantify the lipid extracted from human plasma by liquid chromatography mass spectrometry during high-throughput plasma lipidomics.

Biochem/physiol Actions

C8 Dihydroceramide (d18:0/8:0) or N-octanoyl-D-erythro-sphinganine, is a synthetic dihydroceramide. Dihydroceramide acts as a precursor for de-novo ceramide synthesis. C8 Dihydroceramide mimics γ-tocotrienol (γTE) in stimulating NF-κB-target protein A20 expression, increasing endoplasmic reticulum (ER) stress and reducing tumor necrosis factor (TNF)-triggered nuclear factor kappa B (NF-κB) activation.

Packaging

5 mL Amber Glass Screw Cap Vial (860626P-5mg)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Vitamin E gamma-tocotrienol inhibits cytokine-stimulated NF-kappaB activation by induction of anti-inflammatory A20 via stress adaptive response due to modulation of sphingolipids
Wang Y, et al.
Journal of Immunology, 195(1), 126-133 (2015)
Yun Wang et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 126-133 (2015-05-24)
NF-κB plays a central role in pathogenesis of inflammation and cancer. Many phytochemicals, including γ-tocotrienol (γTE), a natural form of vitamin E, have been shown to inhibit NF-κB activation, but the underlying mechanism has not been identified. In this study...
Jennifer T Saville et al.
Journal of inherited metabolic disease, 43(3), 558-563 (2019-11-11)
Gaucher disease (GD) is an inherited metabolic disorder characterised by impaired catabolism of the glycosphingolipid, glucosylceramide. The deacetylated derivative, glucosylsphingosine (GluSph, lyso-Gb1) has materialised as a biomarker for GD. Further appraisal of the clinical utility of GluSph is required in...
Low serum levels of (dihydro-) ceramides reflect liver graft dysfunction in a real-world cohort of patients post liver transplantation
Mucke V, et al.
International Journal of Molecular Sciences, 19(4), 991-991 (2018)
Victoria Therese Mücke et al.
International journal of molecular sciences, 19(4) (2018-03-29)
Patients after orthopic liver transplantation (OLT) are at risk of developing graft dysfunction. Sphingolipids (SL's) have been identified to play a pivotal role in the regulation of hepatocellular apoptosis, inflammation and immunity. We aimed to investigate the serum SL profile...

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