860662P

Avanti

Sphingosine-1-Phosphate (d20:1)

D-erythro-sphingosine-1-phosphate (C20 base), powder

Empirical Formula (Hill Notation):
C20H42NO5P
CAS号:
分子量:
407.52
NACRES:
NA.25
价格与库存信息目前不能提供

form

powder

packaging

pkg of 1 × 1 mg (860662P-1mg)

mfr. no.

Avanti Polar Lipids, 860662P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O

General description

Sphingosine-1-phosphate (S1P) is a zwitterionic sphingolipid. It is found in insects, yeasts and plants. Sphingosine-1-Phosphate (d20:1) is a phosphorylated derivative of long chain base C20 sphingosine.

Application

Sphingosine-1-phosphate (S1P)-d7 has been used as a reference standard in liquid chromatography/tandem mass spectrometry analysis for quantitative analyses of S1P d20:1 in central nervous system of healthy mice and in human glioblastoma tissue.

Biochem/physiol Actions

Sphingosine-1-phosphate (S1P) is an important cellular metabolite and signaling lipid in animal cells. It aids in various physiological and cellular processes such as atherosclerosis, inflammation, immunity, tumorigenesis, and cell proliferation. S1P plays a vital role in mammalian brain and cardiac development. S1P d20:1 serves as a partial agonist at the S1P receptor 2 (S1P2). It has an ability to inhibit S1P d18:1‐mediated cyclooxygenase 2(COX2) induction.

Packaging

5 mL Amber Glass Screw Cap Vial (860662P-1mg)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Henrik Fyrst et al.
Nature chemical biology, 6(7), 489-497 (2010-06-19)
Sphingolipids comprise a complex family of naturally occurring molecules that are enriched in lipid rafts and contribute to their unique biochemical properties. Membrane sphingolipids also serve as a reservoir for bioactive metabolites including sphingosine, ceramide, sphingosine-1-phosphate and ceramide-1-phosphate. Among these...
Michael Maceyka et al.
Trends in cell biology, 22(1), 50-60 (2011-10-18)
The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, atherosclerosis, diabetes and osteoporosis. S1P is produced in cells by two sphingosine kinase isoenzymes, SphK1 and SphK2. Many cells...
Rajkumar Vutukuri et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 3932-3942 (2020-01-17)
Sphingosine 1-phosphate (S1P) signaling influences numerous cell biological mechanisms such as differentiation, proliferation, survival, migration, and angiogenesis. Intriguingly, our current knowledge is based solely on the role of S1P with an 18-carbon long-chain base length, S1P d18:1. Depending on the...

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