860677P

Avanti

C18神经酰胺-d7(d18:1-d7/18:0)

N-stearoyl-D-erythro-sphingosine (d7), powder

Empirical Formula (Hill Notation):
C36H64D7NO3
分子量:
573.00
NACRES:
NA.25
价格与库存信息目前不能提供

form

powder

packaging

pkg of 1 × 1 mg (860677P-1mg)

mfr. no.

Avanti Polar Lipids, 860677P

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

General description

C18神经酰胺(d18:1/18:0)是一种含有鞘氨醇和硬脂酸的合成神经酰胺。C18神经酰胺-d7(d18:1-d7 / 18:0)是神经酰胺d18:1/18:0的氘代衍生物。

Application

C18神经酰胺-d7(d18:1-d7 / 18:0)已被用作液相色谱-质谱(LC-MS)联用法中定量测定骨骼肌中C18神经酰胺的标准品。它还被用作thermo q-exactive质谱和四极杆-静电场轨道阱质谱法测定斑马鱼脑和人胚胎肾细胞系(HEK293)中C35–C39神经酰胺的标准品。

Biochem/physiol Actions

C18神经酰胺参与细胞生长的抑制。测定人血浆中神经酰胺(Cer)d18:1/16:0、Cer d18:1/18:0、Cer d18:1/24:0和Cer d18:1/24:1的水平和比率有助于冠状动脉疾病致命结果的预后。C18神经酰胺d18:1/18:0稳定的同位素形式为其临床规模的测量提供了一种经过验证的新液相色谱-串联质谱分析方法。

Packaging

5 mL 棕色玻璃螺旋盖小瓶 (860677P-1mg)

RIDADR

NONH for all modes of transport

Flash Point(F)

No data available

Flash Point(C)

No data available

Takhar Kasumov et al.
Analytical biochemistry, 401(1), 154-161 (2010-02-25)
We present an optimized and validated liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method for the simultaneous measurement of concentrations of different ceramide species in biological samples. The method of analysis of tissue samples is based on Bligh and...
Paul T Reidy et al.
The Journal of physiology, 596(21), 5217-5236 (2018-09-09)
Insulin sensitivity (as determined by a hyperinsulinaemic-euglyceamic clamp) decreased 15% after reduced activity. Despite not fully returning to baseline physical activity levels, insulin sensitivity unexpectedly, rebounded above that recorded before 2 weeks of reduced physical activity by 14% after the recovery...
Anna Zalewska et al.
Biomolecules, 9(12) (2019-12-19)
This is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (IR). The experiment was conducted on 20 male C57BL/6 mice...
Hady Razak Hady et al.
Journal of clinical medicine, 8(12) (2019-12-18)
The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain whether in obese humans, the...
Tejia Zhang et al.
Scientific reports, 9(1), 19939-19939 (2019-12-29)
Extensive characterisations of the zebrafish genome and proteome have established a foundation for the use of the zebrafish as a model organism; however, characterisation of the zebrafish lipidome has not been as comprehensive. In an effort to expand current knowledge...

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